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The data is earlier-stage and most of the human work comes from outside the U.S

Hanrahan JP, de Boer IH, Bakris GL et al (2021) Effects of the soluble guanylate cyclase stimulator praliciguat in diabetic kidney disease: a randomized placebo-controlled clinical trial

Better glycemic control Thyroid function significantly affects insulin sensitivity

A 2024 systematic review cataloged the preclinical BPC-157 literature and identified a consistent pattern: strong effect sizes in rodent models across multiple injury types, with no dose-limiting toxicity observed at standard experimental doses [10]

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