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The shedding often becomes noticeable two to four months after starting treatment or after significant weight loss, which is a key distinguishing feature

Similar results were reported in the study of Chen et al., where high TMAO levels increased the expression of tumor necrosis factor- (TNF-) and interleukin-6 (IL-6), but inhibited the expression of anti-inflammatory cytokine interleukin-10 (IL-10), thereby accelerating cellular inflammation in obese mice treated with a Western diet (73)

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The timeline matters if youre planning for pregnancy, preparing for surgery, switching to another treatment, or waiting for side effects to fade