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This result was not confirmed in another study evaluating the effects of liraglutide versus placebo on DM2 patients that showed no significant change in EAT or in myocardial triacylglycerol content (a marker of myocardial steatosis) at proton MR spectroscopy [154]
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Despite this, palpitations are not a listed side effect of Ozempic, and currently, there is no evidence to support the notion that Ozempic causes heart palpitations
While human evidence is still limited, the warning remains due to: persistent concern about thyroid proliferation lack of long-term human safety data increased calcitonin levels in some patients Related: Black Box Warnings Potential Long-Term Neurological Effects Because GLP-1 receptors exist in the brain, long-term use may influence: mood regulation cognition reward systems appetite pathways Emerging reports suggest possible risks: depression anxiety emotional blunting reduced hunger signaling long-term Research is ongoing
In RAW 264.7 macrophages, CME therapy decreased nitric oxide and inducible nitric oxide synthase (iNOS) in the LPS-induced inflammatory response [250]
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