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Tucker M, Keely A, Park JY, et al
Using simple sterile water opens the door to contamination that can feast on the peptide, rapidly degrading it within days
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Thus, although negative selection against VAMP1 reduces cleavage on SNARE targets, evolution on procaspase-1 appears to confer caspase-like substrate preferences that include IL-1 or substrates with complete homology to the P2P4 of procaspase-1 such as ORC1 (residues 691707)
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eClin Med 58:101883 Woelfer M, Kasties V, Kahlfuss S, Walter M (2019) The role of depressive subtypes within the neuroinflammation hypothesis of major depressive disorder
