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For the millions of years before we began to sharpen spears, mill grains, or boil sugarcane, our entire physiology is presumed to have evolved in the context of eating what our great ape cousins did: a diet comprised of leaves, roots, fruits, and nuts

they are standard operating procedures in any serious research environment

Chin J Integr Med 2013

It can also decrease the cellular action of circulating thyroid hormones, potentially interfering with medications like Levothyroxine used for hypothyroidism, which could paradoxically worsen fatigue if unmonitored