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A high extracellular glutamate concentration was one of the first xCT inhibitors described but a few years later, erastin (standing for eradicator of RAS and small T antigen-expressing cells) was identified by Stockwell's group in RAS-mutated cancer cell lines as inhibitor of xCT transport (42)
Studies demonstrate protection against diabetes, obesity, cardiovascular disease, kidney disease, liver disease, neurodegeneration, and cancer through comprehensive metabolic optimization
Similarly, increased export of GSSG also occurred, potentially contributing to lower intracellular levels
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Patients with elevated SAH frequently have more than an isolated methylation problem
10.3390/antiox12081500 124 PhillipsC.FahimiA
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