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With these points in mind, we undertook a broad assessment of published clinical data, curating the body weight loss (% from baseline), glycosylated hemoglobin levels (HbA1c), and nausea responses (% patients reporting) from the SUSTAIN 3, SUSTAIN 7, SCALE Diabetes, SURPASS 2, and STEP 2 trials (17, 22, 64, 66, 67) ( Figures 1AC )
Slower dose titration significantly improves tolerability for both medications
estimated proportion difference [EDP] = 28.9 percentage points
semaglutide in France at the pre-specified timepoints for cohort 1, for cohort 2, and overall (Supplementary Material, Tables S5a to S5d)
Efficacy and tolerability of GLP-1 agonists in patients with type 2 diabetes mellitus: an Indian perspective
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