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18 Table 4 Time to Improvement of Abnormalities in Vitamin B12 Deficiency After Initiation of Treatment A 2005 Cochrane review involving 108 patients with vitamin B 12 deficiency found that high-dose oral replacement (1 mg to 2 mg per day) was as effective as parenteral administration for correcting anemia and neurologic symptoms

Verify indication

Approach Maximum extension Duration Up to 16 weeks Off Period 4+ weeks Notes Reported anecdotally

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In the absence of, can cause folic acid deficiency, and the resulting DNA synthesis disorder that affects red blood cell development and maturation