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[1] [6] Common dosing protocols in clinical studies have ranged from 600 mg to 1,400 mg per session, administered two to three times per week, though higher or lower doses may be used depending on individual needs

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The molecular mechanisms primarily involve excessive activation of the unfolded protein response triggered by endoplasmic reticulum stress in granulosa cells [350], leading to caspase cascade-dependent apoptosis, as well as DNA strand breaks and membrane lipid peroxidation induced by mitochondrial electron transport chain leakage in spermatozoa [351, 352]

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