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Systemic distribution profile
Given SIRT2s dependence on NAD, its activity is linked to the cellular metabolic state (Wang et al, 2007), providing a sensor mechanism that couples energy metabolism to translational control
Nutritional support Adequate protein intake provides the amino acid substrate for tissue repair
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We therefore propose that tissue-associated oxidative stress may promote conversion of circulating TTR into dsNNTTR locally within the interstitial compartment, rather than exclusively during intracellular synthesis or processing
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