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During exercise, gut microbiota modulate mitochondrial biogenesis via PGC-1/SIRT1/AMPK pathways, and their metabolites (e.g., SCFAs, secondary bile acids) mitigate TNF--mediated immunity and reduce NLRP3 inflammasome activation, thereby regulating mitochondrial energy production and ROS generation to alleviate intestinal inflammation (Clark and Mach, 2017)
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