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An acute anal fissure usually heals within six to eight weeks if treated consistently
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The level of ROS in the body increases with age and as a result of negative lifestyle factors such as smoking [4] and obesity [5]
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The N-terminal of active ERM proteins interacts with the cytosolic domain of the transmembrane CD44 and ICAM-1 proteins, while the C-terminal domain is bound to F-actin (Bretscher, 1999
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