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Conditional deletion of Gpx4 in neurons leads to hippocampal degeneration, astrogliosis, and cognitive impairmentsfeatures that are reversed by ferroptosis inhibition using liproxstatin-1 (289)

There, it binds to the Antioxidant Response Element (ARE) on DNA and switches on the genes responsible for cellular protection

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BCAT2 modulates glutamate levels and counteracts the effects of system Xc inhibitors, protecting against ferroptotic death [34]

As a result, reconstituted peptide solutions remain microbiologically stable across multiple experimental sessions when stored at 4C