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Because roughly 70% of daily GH secretion occurs during slow-wave sleep, this improvement creates a positive feedback loop: deeper sleep triggers more GH release, and higher GH levels promote more restorative sleep patterns
These patients benefit most from sermorelin therapy in the long run but need patience through the initial phase
Metabolomic results confirmed systemic glutathione depletion and mitochondrial dysfunction, as evidenced by reduced levels of S-lactoylglutathione, carnitine species, and NAD+ intermediates
doi: 10.3390/antiox9121310 37
2021 Campos et al
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