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Although participants on semaglutide 2.4 mg had a significant reduction in SBP and DBP compared with placebo, in our ITT analysis, the adjusted mean difference in SBP fell short of statistical significance ( P = 0.059)

Besides the well-known targets such as the inhibition of the mTOR signaling pathway, several additional metformin and phenformin targets (e.g., mGPDH, ATF3, STAT3, GSK3, cyclins) have been identified in other cancers (Thakur et al., 2019)

PMCID: PMC10852736

The choice between them depends on your weight loss goals, side effect tolerance, and physician recommendation

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The study found that all efpeglenatide dosages notably decreased body weight, showing reductions between 6.3 and 7.2 kg compared to the placebo