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To this extent, previous reports have shown that the control of MZB localization in the spleen depends on signals delivered by integrins and chemokines such as ICAM-1 and VCAM-1 16,53

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High levels of -melanocyte-stimulating hormone (-MSH) bind with Melanocortin 1 Receptor, resulting in the activation of adenylyl cyclase and elevation in the level of cellular cAMP, which then activates protein kinase A (PKA)

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