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175 For the PPP enzymes, recent studies have discovered some inhibitors targeting on G6PD, such as NADP + analogs, the competitive inhibitor 6-aminonicotinamide (6-AN), noncompetitive inhibitors epiandrosterone and dehydroepiandrosterone (DHEA) which reduces the availability of NADPH and inhibits the cell growth

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Human Jurkat T cells, eosinophilic leukemia cells, and lung epithelial cells were also utilized by this group to assess the effects of apigenin (1 M)

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These build up over the years through continual stress, pollution, and other external factors

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