Activation of these receptors may reduce the hedonic drive to eat, the pleasure-seeking component of appetite that makes you want to eat even when you are not physically hungry
Enhanced Weight Loss Effects While metformin is generally considered weight-neutral (though some patients experience modest, initial weight loss), tirzepatide is a highly potent weight loss medication

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If you take diphenhydramine, cetirizine, or similar medications regularly, they may be contributing to fatigue that gets attributed to tirzepatide
Dehydration is a well-known cause of muscle cramps, fatigue, and generalized body aches
Thakur, K