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10.1161/CIRCULATIONAHA.108.778019 126 UlmerB
PT-141 Research Applications PT-141 is used in vitro as an MC4R-preferring reference agonist at the human melanocortin receptors, and as a structure-activity probe of the C-terminus
This degradation, in turn, allows NF-B activity to increase, resulting in increased transcription of pro-inflammatory genes, including TNF-, IL-1, IL-6, and inducible nitric oxide synthase (iNOS) (Morgan and Liu, 2011)
The analysis was carried out using a Thermo Scientific Vanquish LC coupled to Thermo Q Exactive HF MS
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