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Physiol Rep (2021) 8(24):e14651
Key astrocyte-specific proteins maintaining water and ionic homeostasis include aquaporin-4 (AQP4) water channels, gap junction proteins (connexin-43, -30, -26) ensuring structural and metabolic syncytial integration, and inwardly rectifying potassium channels Kir4.1 (Zhou et al
Rodriguez PJ, Zhang V, Gratzl S et al
GLP-1s trigger insulin secretion when food is eaten, helping to lower blood glucose levels
Semaglutides clinical efficacy profile , characterised by HbA1c reductions of 1.52.0% and body weight reductions of 1015% with subcutaneous dosing and up to 17% with the higher-dose Wegovy formulation , represents the highest efficacy achieved by any selective GLP-1R agonist and substantially exceeds the outcomes achieved with liraglutide, exenatide, and earlier GLP-1R agonists
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