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Sources New England Journal of Medicine: TripleHormone-Receptor Agonist Retatrutide for Obesity A Phase 2 Trial New England Journal of Medicine: Once-Weekly Semaglutide in Adults with Overweight or Obesity Eli Lilly: News Release: Lillys phase 2 retatrutide results published in The New England Journal of Medicine Clinical Trials Arena: Eli Lilly infiltrates anti-obesity market as Phase III trial for retatrutide begins Eli Lilly: News Release: Lillys tirzepatide shows additional 21.1% weight loss after 12 weeks of intensive lifestyle intervention, for a total mean weight loss of 26.6% from study entry over 84 weeks FDA Label: OZEMPIC (Semaglutide Injection) Medication Guide FDA Label: WEGOVY (Semaglutide Injection) Medication Guide FDA Label: RYBELSUS (Oral Semaglutide) Medication Guide FDA Label: MOUNJARO (Tirzepatide Injection) Medication Guide FDA Label: ZEPBOUND (Tirzepatide Injection) Medication Guide Important Medical Information and Disclaimers Medical Disclaimer This article, Will Retatrutide Be Available in 20262027?, is for educational purposes only and is not intended to replace professional medical advice, diagnosis, or treatment

But with that said, FDA-approved GLP-1s are much safer than compounded alternatives, so it is a good idea to switch to the name-brand medication when possible. He says that there are no strict guidelines on switching, but since the compounded medications are unregulated and dosing may be inaccurate, it is best to start at a low dose with physician supervision, and titrate the medication up per established recommendations