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Very high prolonged doses without medical supervision may stress the kidneys

E., Toplak, H., Scirica, B

Improved control despite reduced medication: The combination of improved insulin sensitivity plus semaglutides direct effects often produces better glucose control than previous multi-drug regimens

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Since CagriSema already contains semaglutide 2.4 mg, transitioning from standalone semaglutide to CagriSema would theoretically be simpler, though clinical guidance on this transition is limited

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