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Rodrguez-Carrio, J

Moreover, G289A and T337I mutations are located proximal to the ATP-binding pocket of the C-terminal domain, G289A would cause steric conflict with Ser293, and T337I would cause a hydrophobic patch on the protein surface and reduce protein solubility

This sensitization effect occurs via the suppression of mitophagy through the FFAR2/PPAR- /PINK1/Parkin axis

Standard reconstitution (recommended): - 10 mg vial + 2 mL bacteriostatic water = 5 mg/mL concentration - At this concentration: 0.1 mL (10 units on an insulin syringe) = 0.5 mg MT-II - 0.05 mL (5 units) = 0.25 mg MT-II Alternative (simpler math): - 10 mg vial + 1 mL bacteriostatic water = 10 mg/mL concentration - At this concentration: 0.05 mL (5 units) = 0.5 mg MT-II - More concentrated, but each unit mark on the syringe represents a larger dose, making small dose adjustments harder Step-by-step mixing: 1

In that case, no action is required