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Among the participants, 1,320 had pre-diabetes at the start of the study, defined by blood sugar levels between 5.7%-6.4%

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Specifically, persistent IFN signaling sustains progressive CD8 + T-cell differentiation toward a terminal-exhausted state, which is associated with the restriction of antitumor immunity and the failure of immune treatment [96, 296]

They have been shown to aid in the transfer of biological information, regulate metabolic processes, and impact cell replication and apoptosis [2]