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Key observation: All dose groups began at 0.5mg with gradual escalation over several weeks before reaching maintenance doses

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You are pharmacologically stimulating melanocytes, or the pigment producing cells in the skin, which raises safety questions, she says

Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and naproxen are generally safe short-term, but chronic NSAID use with semaglutide may increase gastrointestinal ulcer risk

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