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Oxyntomodulin (Glicentin-(33-69)): Pharmacokinetics, Binding to Liver Cell Membranes, Effects on Isolated Perfused Pig Pancreas, and Secretion From Isolated Perfused Lower Small Intestine of Pigs

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moreover, it has been reported that GLP-1RA down-regulated AT1 and up-regulated AT2 in cardiomyocytes, glomerular capillaries and proximal tubules of the renal cortex in rats (73, 74, 77), resulting in a protective effect against ANG II-induced cardiac and kidney fibrosis (73, 74, 77)