These medications: Decrease pro-inflammatory cytokines including TNF-, IL-6, and IL-1 9 Reduce macrophage infiltration in tissues 40 Block NF-B activation, a key inflammation controller 41 Switch macrophages from pro-inflammatory M1 to anti-inflammatory M2 type 40 These effects show promise for various joint conditions
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Chronic inflammatory stress can also worsen fatigue, water retention, joint pain, and metabolic dysfunction
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This move is a clear signal that the future of metabolic therapeutics lies in integrated, multi-pathway approaches that treat the whole system, not just one organ