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Built for Higher Stability: Cyclization (AspLys lactam bridge) plus amino-acid substitutions (e.g., Nle , D-Phe ) help reduce enzymatic breakdown in experimental systems
This differential affinity profile is thought to contribute to Tirzepatides observed downstream signalling characteristics in experimental systems, including distinct cAMP activation patterns relative to single-target incretin analogues
doi:10.1016/j.otohns.2006.07.010
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