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PMID: 2832504

Topical products have a hard time penetrating the skin's protective barrier, which limits their effectiveness

Some runners prefer alternating between the affected Achilles area and abdominal subcutaneous injection

F.AlcornC.Kidwai-KhanF.et al (2021)

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Thus, in response to a sigmoidal gradient, in which the first derivative is symmetric around the gradient's midpoint, the pulsatile response is stronger in the first half, up to the maximal first derivative point, and decreases thereafter (Fig 2B)