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Light water retention or bloating
Type of reaction Enzyme Endogenous conjugating agent Examples of drugs metabolized by the same pathway Glucuronidation UDP- glucuronosyltransferase UDP-Glucoronic acid Chloramphenicol, morphine, paracetamol, salicylic acid, propofol fenoprofen, diazepam Sulfation Sulfotransferases sulfate Paracetamol, salbutamol Glycine/ glutamine conjugation JV-Acyl transferases Glycine Glutamine Cholic acid, salicylic acid, nicotinic acid, phenylacetic acid Glutathione conjugation Glutathione S transferases Glutathione Adriamycin, busulfan, chlorambucil, cis-platin, cyclophosphamide, ethacrynic acid Acetylation N- Acetyl transferases Acetyl-CoA Histamine, procainamide, sulfonamides, isoniazid, hydralazine Methylation Methyl transferase S-Adenosyl-L- methionine Morphine, norephedrine, nicotine, histamine, isoprenaline, propylthiouracil Uridine diphosphate-glucuronosyltransferases Glucuronidation is the most common and the most important conjugation reaction
Doi: Va-Galvn S, Pirmez R, Hermosa-Gelbard , et al
These attributes make it an ideal choice for individuals aiming to optimize body composition while improving energy utilization
Only a limited number of patients who were allergic to allopurinol have been studied to date, but the drug was tolerated in those patients
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