When outcomes were reported at multiple time points, the most recent follow-up data were extracted to maintain consistency across studies
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When these drugs are taken together, there is a higher chance of low blood sugar, known as hypoglycemia, if not managed carefully
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In the context of these co-crystal structures, Compound 24 consistently engaged key conserved hydrophobic residues (M336, L388, F392, and F424) and formed hydrogen bonds with Q421, while additional interactions with H223, Y222, I371, H373, I428, P408, L409, M389, and V417 contributed to specificity (Figures 9AE)
The incidental finding of HAE-nC1-INH causal variants confers the chance to identify and manage a type of HAE-nC1-INH that may otherwise be unrecognized in an individual