Some patients report feeling tired or having reduced energy levels, which may be related to changes in eating patterns or the direct effects of the medication on metabolism
Other growth hormone functions are to increase muscle mass and glucose production in the liver
The trial specifically compared outcomes between groups that started at 2 mg versus those that started at 4 mg to understand how the starting dose affected tolerability
Published trial endpoints show meaningful changes over months, with major body-weight endpoints measured at 24, 48, 68, 80, and 104 weeks
Those include rapid or unexpected intoxication, sudden behavioral changes, memory lapses, hallucinations, paranoia, and an unusual appearance or taste of a drink
Disruption of proteostasis is often accompanied by an imbalance between oxidative stress and antioxidant defense, ultimately promoting germ cell apoptosis (Santiago et al., 2020)