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It is usually well tolerated, but rare serious complications such as VPA-induced hepatotoxicity (VHT) and VPA-induced hyperammonaemic encephalopathy (VHE) may occur in some patients who receive VPA chronically [133]
These are reasonable properties of the individual ingredients at sufficient doses
10.1152/ajprenal.00729.2010 102
Have we been ignoring the elephant in the room
The additive effects on GABAergic signaling create unpredictable sedation depth
Feng et al
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