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Tirzepatide works on both GIP and GLP-1 receptors and is already approved for treating type 2 diabetes

This dual action on both peripheral digestion and central appetite regulation explains why many patients report feeling satisfied with smaller portions and experiencing reduced interest in food

Patients with Fitzpatrick IV-VI skin should be monitored for potential irritation during initial use, particularly in combination with other actives, and formulations should be pH-controlled (pH 3.5 or lower for efficacy without excessive irritation)

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