In rare cases, they can cause more serious side effects such as: Pancreatitis (inflammation of the pancreas) Hypoglycemia (low blood sugar) Kidney problems Gallbladder problems Allergic reactions Patients should seek immediate medical attention if they experience symptoms such as severe abdominal pain, persistent nausea or vomiting, rapid heartbeat, difficulty breathing, or swelling of the face, lips, tongue, or throat
A 2021 study published in Nature Microbiology identified a protein called P9, secreted by Akkermansia muciniphila, that was sufficient to induce GLP-1 secretion and brown adipose tissue thermogenesis in mice on a high-fat diet
Metabolic Dysfunction-Associated Fatty Liver Disease (MASLD): Retatrutide can reduce liver fat content by 86%, and more than 85% of patients achieve regression of liver steatosis
In fat cells, it increases thermogenesis and lipolysis, further driving the conversion of free fatty acids to ketone bodies
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PMID: 40445127.