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Kynurenine secreted from tumors induces cytotoxic CD8 T-cell death, enhancing immune evasion during metastasis 10

"Degradable redox-responsive disulfide-based nanogel drug carriers via dithiol oxidation polymerization"

Campbell S, Marriott M, Nahmias C, MacQueen GM

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Study Duration: 8-12 weeks

308,309 EMT, CSCs, and DTPs are interconnected via regulatory networks involving transcription factors (e.g., SNAIL, ZEB1), 318 signaling cascades (e.g., TGF-), and cues from the TME (e.g., CAFs, hypoxia), collectively sustaining tumor heterogeneity and adaptive resistance