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Although evidence on sex differences in semaglutides weight loss efficacy remains controversial, several hypotheses have been proposed to explain why females may experience greater weight reduction than males: 1) Pharmacokinetic differences: females often exhibit higher plasma levels of GLP-1 RAs due to lower BW and slower drug clearance compared with males, resulting in increased exposure to the medication and potentially greater weight loss [55,56,57]

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Spicy or acidic foods: While tolerance varies individually, some patients report that heavily spiced dishes or acidic items (citrus, tomato-based sauces) worsen nausea or reflux symptoms

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Hence, GLP-1 may be key to improving cognitive decline in patients with depression