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Quantitative endpoints, such as MRI-PDFF and histology, can capture subtle yet clinically meaningful changes, whereas ALT/AST and ultrasonography may miss early metabolic improvements
Rybelsus (semaglutide) is a convenient alternative to weekly injections, but the medication does not have the same efficacy as injectable medications (Wegovy)
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Furthermore, some medications are only indicated for short term use (12 weeks or less)
This pattern works exceptionally well during the first weeks of treatment or after dose increases, when side effects are most pronounced
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