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Blood pressure, which often improves with weight loss

Its effects on glycemic control and body weight depend on sustained GLP-1 receptor occupancy over days to weeks, not on achieving specific peak concentrations ( Variability-sensitive pharmacodynamics (peak-driven, dose-critical effects): When effects are peak-driven or the therapeutic window is narrow, variability directly translates into clinical harm

Both hormonal and nonhormonal options can be used

These constructs are related but not interchangeable and are addressed at different mechanistic levels throughout the manuscript

Similarly, the specific blocking of Gq signalling with YM254890 or transient receptor potential melastatin 5 (TRPM5) with triphenylphosphine oxide (TPPO) suppressed the triagonist-induced enhancement of GSIS

Diabetes Obes Metab , 2022 (open-access)