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While the preclinical evidence base is extensive and the safety profile appears favorable, large-scale randomized controlled trials in humans have not been completed

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Clinical trials on tesamorelin, another GHRH mimetic, have observed noteworthy improvements in muscle density and size among HIV patients

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Institutional Requirements Academic and commercial research facilities maintain strict protocols

This tool includes seven domains: 1) bias due to confounding, 2) bias in selection of participants into the study, 3) bias in classification of interventions, 4) bias due to deviations from intended interventions, 5) bias due to missing data, 6) bias in measurement of outcomes, and 7) bias in selection of the reported results