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The maximum dose is 2 mg per week (compared to Wegovy's 2.4 mg), but the weight-loss difference is modest (12% to 14% total body weight loss on Ozempic 2 mg vs 15% to 17% on Wegovy 2.4 mg, per the STEP and SUSTAIN trial data)

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Over the 20th century, additional treatments were developed and FDA approved for treatment of overweight and obesity, including phentermine, phentermine/topiramate, orlistat, and naltrexone/bupropion

Lucas et al

Practical Steps for Sustainable Low-Dose Semaglutide Therapy Successful low-dose semaglutide journeys combine medication consistency with intentional nutrition and movement changes

In January 2023, Novo Nordisk announced that the FDA had approved a label update for the drug