This decline is associated with reduced energy, mental fatigue, slower cellular repair, and decreased resilience to stress
2225 As much of the evidence base reporting benefits across domains of psychopathology is comprised of persons whose primary diagnosis is either obesity and/or T2DM, the question arises as to whether the psychiatric benefit can be parsimoniously explained as pseudo-specific and a consequence of improvement in anthropometrics and metabolism
But the marketplace for these medications has gone haywire
GLP-1 is what is known as a glucagon-like peptide-1 (GLP-1) receptor agonist, acting in much the same way as GLP-1, a hormone that is released from the intestine following a meal
Meta-analyses show that supplementation is a safe and effective way to increase muscle creatine concentrations, promoting the associated benefits
However, results are modest without a caloric deficit