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3 Because enzyme DPP-4 is mainly located on the surface of the intestinal cells, a large portion of GLP-1 is degraded to inactive metabolites, and only 25% of GLP-1 reaches the blood circulation
Glucagon, the hormone that raises blood sugar, gets suppressed
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Because of this, it can be more potent than medications that act on only one pathway
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Cell Metab (2017) 26(2):34352.e2.10.1016/j.cmet.2017.07.011 103 GasbjergLSGabeMBNHartmannBChristensenMBKnopFKHolstJJet alGlucose-dependent insulinotropic polypeptide (GIP) receptor antagonists as anti-diabetic agents
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