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By converting to its active forms within the body, it supports methylation and the synthesis of nucleic acids and amino acids, which are vital for maintaining healthy nerve cells and forming red blood cells, thus correcting Vitamin B12 deficiency and associated symptoms

Thus, where genotype is known, there is a strong case for initiating serum vitamin B 12 monitoring from initiation of metformin treatment in people with the AA genotype but deferring this until 10 years of treatment in the rest of the population who have no other risk factors

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