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Rather than treating these domains independently, we propose a unifying framework in which melatonin functions as a physiological hub coordinating temporal organization and cellular protection
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Overall, we identified that adjunctive use of bestatin (protease inhibitor), imatinib (tyrosine kinase inhibitor), roflumilast [phosphodiesterase-4 inhibitor (PDE-4)], or palacaparib [Poly(ADP-ribose) polymerase 1, PARP-1 inhibitor] significantly reduced both mortality (compared to the control arm, adjunctive dexamethasone) and neurological deficits (compared to the control arm, TB treatment alone)
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Researchers found that individuals with insomnia have decreased glutathione levels
The FDA-approved dosing regimens have been rigorously tested for safety and efficacy
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