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J Clin Invest (2005) 115:162735
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The impact of oxidative stress in diabetes is particularly evident in its complications
Major diseases such as cancer and cardiovascular ailments can be associated with inflammation caused by oxidative stress
It upregulated p21 waf1/cip1 , p53, Fas, p53 upregulated modulator of apoptosis (PUMA), caspase-3 or caspase-8, and downregulated Bcl-2 in favor to cell-cycle arrest of the tumor cells
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