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Endorsed by the Heart Failure Society of America and the Heart Failure Association of the European Society of Cardiology

However, for patients undergoing frequent UDS testing, selecting an agent least likely to cause false-positives would be an important consideration to help minimize adverse consequences to patients from potentially misinterpreted results

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This may be due to the fact that bile acids entering the intestine stimulate intestinal secretion and expression of the gut-derived hormone FGF19 via bile acid-FXR signaling (Mulla et al., 2019), which stimulates hepatic glycogen synthesis in an insulin non-dependent manner, restrains hepatic gluconeogenesis, and exerts hypoglycemic effects

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