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In summary, enhancing mitochondrial biogenesis through gene therapy can be achieved either by delivering genes like PGC-1 and TFAM via AAV, or by regulating the expression of relevant factors in monocytes through preoperative ex vivo lentiviral transfectionboth contributing to preconditioning for elective surgeries

Though peptides are sensitive to moisture and temperature changes, many are stable in cool, dry conditions, away from light

Warning: Folic acid should never be given alone when B12 deficiency is suspected, as this can worsen neurological damage

10.1080/87559129.2021.1906697 31 BoshtamM.KouhpayehS.AminiF.AziziY.NajafluM.ShariatiL.et al (2021)

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