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Tirzepatide (LY3298176) in Participants With Type 2 Diabetes Not Controlled With Diet and Exercise Alone (SURPASS) studies have shown that tirzepatide reduced HbA1c and fasting glucose levels more than the titrated insulin degludec, insulin glargine or 1 mg once a week semaglutide independently of the baseline levels of HbA1c
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Ochronosis: A darker, paradoxical mottling of the skin, mainly with prolonged use beyond the recommended period
However, as discussed next, a bona fide indication for GLP-1 RAs to reduce the risk of developing HF or to treat chronic HF arguably requires the resolution of several unknowns
Presented for research literature review only Shetty NP et al
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