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339,340,341 During reperfusion after myocardial infarction, downregulation of zinc transporter ZIP7 increases mitochondrial zinc ions, leading to mitochondrial depolarization and up-regulation of the PINK1-Parkin pathway, which enhanced mitophagy and reduced infarct size
As a class, the top five GLP-1s are already bigger than oncology heavyweights Keytruda and Darzalex, the second-largest oncology drug
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